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  • 2022-08-24

    全自動溶(rong)(rong)出(chu)(chu)(chu)(chu)儀14杯、12桿,電動同(tong)步,可(ke)以實(shi)現獨(du)立(li)投藥、顆(ke)粒劑投藥,有獨(du)立(li)補(bu)液杯,有等溫(wen)補(bu)液的(de)功能,溶(rong)(rong)媒溫(wen)度監(jian)測,取樣點(dian)可(ke)以進行自動定位(wei)等優勢。溶(rong)(rong)出(chu)(chu)(chu)(chu)儀使(shi)(shi)(shi)用是否正確直接關系到溶(rong)(rong)出(chu)(chu)(chu)(chu)試驗的(de)溶(rong)(rong)出(chu)(chu)(chu)(chu)效果,而且操作不當,很(hen)容(rong)易(yi)造成儀器的(de)毀壞(huai)。溶(rong)(rong)出(chu)(chu)(chu)(chu)儀使(shi)(shi)(shi)用要注意什么呢?給大家(jia)做(zuo)下(xia)解答。溶(rong)(rong)出(chu)(chu)(chu)(chu)試驗前期的(de)準備(bei)工作介紹(shao):1、安裝調整(zheng)溶(rong)(rong)出(chu)(chu)(chu)(chu)儀轉(zhuan)(zhuan)桿升(sheng)起機頭,安裝試驗轉(zhuan)(zhuan)桿(籃桿、槳(jiang)桿、小(xiao)槳(jiang)桿)。按一下(xia)上升(sheng)(下(xia)降)鍵(jian)機頭開始上升(sheng)(下(xia)降),再按一下(xia)上升(sheng)或下(xia)降鍵(jian),機頭停止上下(xia)運動。將限位(wei)器撥至基準位(wei)置,按下(xia)降鍵(jian)使(shi)(shi)(shi)機...

  • 2022-08-19

    凝(ning)(ning)膠(jiao)貼膏(gao)是(shi)指原料(liao)藥(yao)(yao)物(wu)與親水(shui)(shui)性適(shi)宜的(de)基質混合后鋪設在背襯材(cai)(cai)料(liao)上制成的(de)貼膏(gao)劑(ji)。凝(ning)(ning)膠(jiao)貼膏(gao)具有含水(shui)(shui)量較(jiao)高(gao)、透(tou)氣性較(jiao)好、載(zai)藥(yao)(yao)量大(da)、吸收效率高(gao)、無異(yi)味、皮膚刺激性小等優點(dian),更易被患者和臨床醫生所(suo)接受,已(yi)成為經(jing)皮給藥(yao)(yao)系統(tong)發展的(de)熱(re)門方向之(zhi)一(yi)。凝(ning)(ning)膠(jiao)膏(gao)劑(ji)通(tong)常采用高(gao)分(fen)子材(cai)(cai)料(liao)為骨架材(cai)(cai)料(liao),再加入(ru)交(jiao)聯劑(ji)、保濕劑(ji)、填充劑(ji)以及透(tou)皮促滲(shen)劑(ji)等形成具有一(yi)定粘度的(de)假塑(su)性流(liu)體(ti)。在使用時(shi),藥(yao)(yao)物(wu)成分(fen)會從骨架材(cai)(cai)料(liao)中釋(shi)放出來并到(dao)達皮膚表面,進而經(jing)過表皮進入(ru)血液循環發揮作用。所(suo)以,凝(ning)(ning)膠(jiao)膏(gao)劑(ji)的(de)藥(yao)(yao)物(wu)成分(fen)的(de)釋(shi)放速(su)率和透(tou)皮吸收速(su)率將直...

  • 2022-08-16

    全自動溶出儀(yi)的(de)(de)校(xiao)(xiao)(xiao)準(zhun)方法(fa)(fa)及注意事項全自動溶出儀(yi)的(de)(de)校(xiao)(xiao)(xiao)準(zhun)方法(fa)(fa):校(xiao)(xiao)(xiao)準(zhun)主(zhu)(zhu)要有(you)機(ji)械方法(fa)(fa)和(he)(he)化學(xue)方法(fa)(fa)兩種。機(ji)械方法(fa)(fa)分(fen)為外觀檢(jian)(jian)查(cha)、轉(zhuan)桿垂(chui)直度和(he)(he)擺動幅(fu)度校(xiao)(xiao)(xiao)準(zhun)、轉(zhuan)速(su)誤(wu)(wu)差(cha)校(xiao)(xiao)(xiao)準(zhun)、控溫誤(wu)(wu)差(cha)校(xiao)(xiao)(xiao)準(zhun)和(he)(he)計時器誤(wu)(wu)差(cha)校(xiao)(xiao)(xiao)準(zhun)。1、外觀檢(jian)(jian)查(cha)主(zhu)(zhu)要采用目(mu)測的(de)(de)方法(fa)(fa),大致對(dui)被檢(jian)(jian)溶出儀(yi)的(de)(de)外觀情況(kuang)作出評判(pan)。包括溶出儀(yi)是(shi)零部(bu)件是(shi)否(fou)齊全;溶出杯(bei)、轉(zhuan)桿等是(shi)否(fou)有(you)破(po)損,溫度時間(jian)等顯示部(bu)分(fen)是(shi)否(fou)有(you)缺字;2、轉(zhuan)桿垂(chui)直度校(xiao)(xiao)(xiao)準(zhun),選用直角(jiao)尺或傾角(jiao)儀(yi)觀察(cha)其(qi)垂(chui)直度;3、擺動幅(fu)度校(xiao)(xiao)(xiao)準(zhun),主(zhu)(zhu)要用百分(fen)表對(dui)轉(zhuan)桿和(he)(he)轉(zhuan)籃(lan)的(de)(de)擺動量(liang)進(jin)行測量(liang);4、轉(zhuan)速(su)誤(wu)(wu)差(cha)的(de)(de)校(xiao)(xiao)(xiao)準(zhun)可以(yi)用非接觸式(shi)的(de)(de)...

  • 2022-08-10

    流通池(chi)法(fa)(fa)是一(yi)種廣泛使用(yong)的新(xin)型(xing)溶(rong)(rong)(rong)出度方(fang)法(fa)(fa),美國(guo)藥(yao)(yao)典(dian)(dian)、歐洲藥(yao)(yao)典(dian)(dian)、日本藥(yao)(yao)典(dian)(dian)等均(jun)有(you)收載。其用(yong)途(tu)廣泛,適用(yong)于幾乎所(suo)有(you)藥(yao)(yao)物(wu)劑(ji)型(xing)的釋放度實驗。特(te)別是針對難溶(rong)(rong)(rong)性藥(yao)(yao)物(wu)、控(kong)釋/緩釋制劑(ji)、植入劑(ji)、半固體制劑(ji)、微球、混懸劑(ji)、脂質體等特(te)殊藥(yao)(yao)物(wu)類型(xing),能夠(gou)提(ti)供比傳統(tong)溶(rong)(rong)(rong)出方(fang)法(fa)(fa)更優的實驗效果。銳拓(tuo)RT7流池(chi)法(fa)(fa)溶(rong)(rong)(rong)出系統(tong)包(bao)括(kuo):流通池(chi)溶(rong)(rong)(rong)出裝置、溶(rong)(rong)(rong)媒(mei)輸送(song)工作站(zhan)和(he)(he)自動取樣(yang)工作站(zhan)。可升(sheng)級(ji)到UV或(huo)HPLC在(zai)線(xian)檢測,可升(sheng)級(ji)與(yu)滲(shen)透系統(tong)聯用(yong)。銳拓(tuo)RT7的設計和(he)(he)性能滿足2020版中國(guo)藥(yao)(yao)典(dian)(dian)溶(rong)(rong)(rong)出度與(yu)釋放度測定第六(liu)法(fa)(fa)、美國(guo)藥(yao)(yao)典(dian)(dian)溶(rong)(rong)(rong)出裝置4...

  • 2022-07-25

    溶(rong)(rong)(rong)(rong)媒(mei)制(zhi)(zhi)備(bei)儀(yi)是如何進(jin)(jin)行真(zhen)(zhen)空脫氣(qi)(qi)的(de)(de)溶(rong)(rong)(rong)(rong)媒(mei)制(zhi)(zhi)備(bei)儀(yi)采(cai)用的(de)(de)是采(cai)用加(jia)(jia)熱、循環(huan)、抽真(zhen)(zhen)空三法合一的(de)(de)真(zhen)(zhen)空脫氣(qi)(qi)方法。可對溶(rong)(rong)(rong)(rong)出(chu)實驗常用的(de)(de)水、鹽酸溶(rong)(rong)(rong)(rong)液(ye)、磷酸鹽緩沖液(ye)等多(duo)種溶(rong)(rong)(rong)(rong)出(chu)介質(zhi)均可進(jin)(jin)行脫氣(qi)(qi),單次能(neng)處理15L溶(rong)(rong)(rong)(rong)出(chu)介質(zhi),液(ye)晶屏顯示和觸(chu)控操(cao)作,交互界面簡單直觀。同時還支持手柄直接操(cao)作和控制(zhi)(zhi),單人即可獨立完成溶(rong)(rong)(rong)(rong)出(chu)介質(zhi)脫氣(qi)(qi)和加(jia)(jia)注工作,操(cao)作簡便,效率高,性能(neng)優(you)(you)勢非常明顯。溶(rong)(rong)(rong)(rong)媒(mei)制(zhi)(zhi)備(bei)儀(yi),比普通的(de)(de)脫氣(qi)(qi)儀(yi)擺脫了溶(rong)(rong)(rong)(rong)媒(mei)對儀(yi)器的(de)(de)限制(zhi)(zhi),脫氣(qi)(qi)體積更(geng)大,對溶(rong)(rong)(rong)(rong)媒(mei)脫氣(qi)(qi)儀(yi)的(de)(de)脫氣(qi)(qi)效率更(geng)高,而且(qie)還具(ju)有預約功能(neng)。溶(rong)(rong)(rong)(rong)媒(mei)制(zhi)(zhi)備(bei)儀(yi)性能(neng)優(you)(you)勢:1設計緊湊(cou)...

  • 2022-07-18

    溶(rong)(rong)(rong)(rong)出(chu)(chu)儀氣(qi)泡(pao)(pao)擴(kuo)散器的(de)作用?礦(kuang)(kuang)(kuang)物(wu)(wu)質(zhi)(zhi)(zhi)(zhi)一般溶(rong)(rong)(rong)(rong)解(jie)在水中(zhong)(zhong),通過沖洗,攪拌或氣(qi)泡(pao)(pao)擴(kuo)散器的(de)作用,逐(zhu)(zhu)步(bu)深入整(zheng)(zheng)個(ge)溶(rong)(rong)(rong)(rong)解(jie)質(zhi)(zhi)(zhi)(zhi)中(zhong)(zhong)去,溶(rong)(rong)(rong)(rong)解(jie)質(zhi)(zhi)(zhi)(zhi)中(zhong)(zhong)的(de)礦(kuang)(kuang)(kuang)物(wu)(wu)質(zhi)(zhi)(zhi)(zhi)與(yu)空氣(qi)接(jie)觸不多(duo),溶(rong)(rong)(rong)(rong)解(jie)質(zhi)(zhi)(zhi)(zhi)隨著(zhu)溶(rong)(rong)(rong)(rong)解(jie)過程(cheng)的(de)進行(xing),與(yu)礦(kuang)(kuang)(kuang)物(wu)(wu)質(zhi)(zhi)(zhi)(zhi)的(de)結合反(fan)應,逐(zhu)(zhu)步(bu)析出(chu)(chu),與(yu)氣(qi)泡(pao)(pao)擴(kuo)散混合,達到飽和(he)溶(rong)(rong)(rong)(rong)解(jie)時,都析出(chu)(chu),充滿整(zheng)(zheng)個(ge)溶(rong)(rong)(rong)(rong)解(jie)質(zhi)(zhi)(zhi)(zhi)中(zhong)(zhong)去,充滿中(zhong)(zhong)心部位溶(rong)(rong)(rong)(rong)解(jie)在溶(rong)(rong)(rong)(rong)液中(zhong)(zhong)的(de)鈣,鎂,鈉,鉀,鋁(lv)的(de)物(wu)(wu)質(zhi)(zhi)(zhi)(zhi)。這部分離子的(de)溶(rong)(rong)(rong)(rong)解(jie)度隨著(zhu)溶(rong)(rong)(rong)(rong)解(jie)過程(cheng)逐(zhu)(zhu)步(bu)減小(xiao),從(cong)而(er)使(shi)礦(kuang)(kuang)(kuang)物(wu)(wu)質(zhi)(zhi)(zhi)(zhi)析出(chu)(chu)少,從(cong)而(er)減小(xiao)空氣(qi)與(yu)溶(rong)(rong)(rong)(rong)解(jie)質(zhi)(zhi)(zhi)(zhi)的(de)接(jie)觸面積,從(cong)而(er)達到均(jun)勻的(de),充分的(de),溶(rong)(rong)(rong)(rong)解(jie)在溶(rong)(rong)(rong)(rong)液中(zhong)(zhong)去,降低礦(kuang)(kuang)(kuang)物(wu)(wu)質(zhi)(zhi)(zhi)(zhi)析出(chu)(chu)量的(de)作用,首先(xian)這個(ge)問題(ti)還是有點...

  • 2022-07-18

    溶(rong)(rong)出度技術中(zhong)的(de)(de)(de)籃法(fa)(fa)和槳(jiang)法(fa)(fa)較早作為質(zhi)量控制(zhi)方法(fa)(fa)被廣泛應用(yong),但由于(yu)溶(rong)(rong)出介(jie)質(zhi)的(de)(de)(de)體(ti)積、溶(rong)(rong)出裝置(zhi)(zhi)及(ji)(ji)流體(ti)動(dong)(dong)力學(xue)特征等與體(ti)內生(sheng)理環境的(de)(de)(de)差異,存在一(yi)(yi)定的(de)(de)(de)局限性(xing)。除籃法(fa)(fa)與槳(jiang)法(fa)(fa)外,還有一(yi)(yi)種往(wang)復筒(tong)法(fa)(fa)。往(wang)復筒(tong)法(fa)(fa)的(de)(de)(de)儀器(qi)(qi)主(zhu)要由多排平(ping)底(di)(di)圓(yuan)柱形(xing)溶(rong)(rong)出杯(bei)、內部的(de)(de)(de)兩端帶(dai)有塑料材(cai)質(zhi)帽子的(de)(de)(de)玻璃(li)往(wang)復筒(tong)、尼(ni)龍或不銹鋼材(cai)料制(zhi)成的(de)(de)(de)抗吸附(fu)篩網、帶(dai)動(dong)(dong)往(wang)復筒(tong)在玻璃(li)容器(qi)(qi)內垂直往(wang)復運動(dong)(dong)的(de)(de)(de)金屬棒以(yi)及(ji)(ji)加熱水(shui)浴(yu)槽組成在測定過(guo)程(cheng)中(zhong),將裝有溶(rong)(rong)出介(jie)質(zhi)的(de)(de)(de)圓(yuan)柱形(xing)溶(rong)(rong)出杯(bei)置(zhi)(zhi)于(yu)恒溫水(shui)浴(yu)中(zhong),將樣品放置(zhi)(zhi)在玻璃(li)往(wang)復筒(tong)中(zhong),篩網裝在往(wang)復筒(tong)頂(ding)部和底(di)(di)部,然后將塑料帽與金...

  • 2022-06-27

    銳(rui)拓儀器RT612-12杯手動取(qu)(qu)(qu)樣(yang)(yang)溶(rong)(rong)出(chu)(chu)儀是(shi)按照《中國(guo)藥(yao)典》和(he)《美(mei)國(guo)藥(yao)典》以(yi)(yi)及《藥(yao)物溶(rong)(rong)出(chu)(chu)度儀機械驗(yan)證(zheng)指導原則(ze)》要求而全新設計(ji)制造(zao)的高性能的12杯12桿溶(rong)(rong)出(chu)(chu)度試驗(yan)裝置(zhi)。其機械參數精(jing)準(zhun)(zhun)(zhun),性能穩定(ding),且擁有(you)*符合(he)數據完整性的操作系(xi)統,適用于各種標準(zhun)(zhun)(zhun)化的溶(rong)(rong)出(chu)(chu)測試。銳(rui)拓儀器RT612-12杯手動取(qu)(qu)(qu)樣(yang)(yang)溶(rong)(rong)出(chu)(chu)儀特點(dian):自(zi)動同(tong)步投(tou)藥(yao)?標配自(zi)動投(tou)藥(yao)模塊,可(ke)以(yi)(yi)實(shi)現(xian)所有(you)樣(yang)(yang)品自(zi)動同(tong)步投(tou)藥(yao),投(tou)藥(yao)時間點(dian)可(ke)以(yi)(yi)被(bei)系(xi)統記錄和(he)審計(ji)追蹤。?投(tou)藥(yao)后,取(qu)(qu)(qu)樣(yang)(yang)時間自(zi)動計(ji)時,到達取(qu)(qu)(qu)樣(yang)(yang)時間點(dian)前,會有(you)提示鳴響。靈活(huo)精(jing)準(zhun)(zhun)(zhun)的取(qu)(qu)(qu)樣(yang)(yang)方式?取(qu)(qu)(qu)樣(yang)(yang)...

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