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  • 2023-01-06

    流(liu)池法(fa)溶(rong)(rong)(rong)(rong)出(chu)度(du)(du)方法(fa)(FlowThroughCellmethod)是一(yi)種(zhong)新型的溶(rong)(rong)(rong)(rong)出(chu)度(du)(du)檢查(cha)方法(fa),已(yi)收錄于歐(ou)洲藥(yao)(yao)典,美國藥(yao)(yao)典,日本藥(yao)(yao)典中,它(ta)可(ke)(ke)克服(fu)日前槳法(fa)、籃法(fa)無法(fa)解決的困難(nan),比槳法(fa)的感知(zhi)度(du)(du)更(geng)高,可(ke)(ke)克服(fu)因藥(yao)(yao)片崩潰堆積所導(dao)致的飽和(he)等(deng)問題。不僅適用于片劑(ji)(ji)、膠囊劑(ji)(ji)釋制(zhi)劑(ji)(ji)的溶(rong)(rong)(rong)(rong)出(chu)度(du)(du)測(ce)定,更(geng)可(ke)(ke)對粉末、栓劑(ji)(ji)、顆(ke)粒(li)劑(ji)(ji)和(he)植入劑(ji)(ji)等(deng)多種(zhong)劑(ji)(ji)型直接測(ce)試,在制(zhi)藥(yao)(yao)公司研究制(zhi)劑(ji)(ji),或原研藥(yao)(yao)變更(geng)劑(ji)(ji)型等(deng)研究中得到(dao)(dao)大量應用。銳拓RT7流(liu)池法(fa)溶(rong)(rong)(rong)(rong)出(chu)系統(tong)包括:流(liu)通池溶(rong)(rong)(rong)(rong)出(chu)裝置、溶(rong)(rong)(rong)(rong)媒輸送工(gong)作站和(he)自動取樣工(gong)作站。可(ke)(ke)升級(ji)到(dao)(dao)UV或HPLC...

  • 2022-12-16

    溶(rong)出(chu)(chu)(chu)儀(yi)采(cai)(cai)(cai)用(yong)雙排(pai)結構(gou)形式(shi)(shi),并(bing)采(cai)(cai)(cai)用(yong)雙區設計,可(ke)在實(shi)(shi)驗(yan)(yan)(yan)溫度相同(tong)的情況下,同(tong)時(shi)分(fen)區進行(xing)不(bu)(bu)同(tong)種類固體制劑、不(bu)(bu)同(tong)方(fang)法(fa)、不(bu)(bu)同(tong)轉速,不(bu)(bu)同(tong)溶(rong)出(chu)(chu)(chu)介質體積的藥物溶(rong)出(chu)(chu)(chu)度實(shi)(shi)驗(yan)(yan)(yan),有效地(di)提(ti)高了儀(yi)器使用(yong)率(lv)。同(tong)時(shi),可(ke)一鍵切換至全溶(rong)出(chu)(chu)(chu)實(shi)(shi)驗(yan)(yan)(yan)模式(shi)(shi),進行(xing)單(dan)一批次藥物全溶(rong)出(chu)(chu)(chu)曲線(xian)試驗(yan)(yan)(yan)。適(shi)用(yong)于大(da)、中、小型藥品(pin)生產廠(chang)家(jia)、藥物科研院所等進行(xing)固體制劑藥物溶(rong)出(chu)(chu)(chu)試驗(yan)(yan)(yan)的單(dan)位或實(shi)(shi)驗(yan)(yan)(yan)室。該儀(yi)器機(ji)頭(tou)可(ke)電動升降,采(cai)(cai)(cai)用(yong)液晶觸摸屏,菜單(dan)式(shi)(shi)操作。本溶(rong)出(chu)(chu)(chu)儀(yi)具有取樣選點(dian)定(ding)時(shi)提(ti)醒、轉速分(fen)區顯示、實(shi)(shi)驗(yan)(yan)(yan)參數打印、提(ti)前預熱、定(ding)時(shi)關機(ji)等功能(neng)。水浴(yu)箱采(cai)(cai)(cai)用(yong)快速插接進...

  • 2022-12-05

    溶(rong)(rong)(rong)出(chu)(chu)度儀是(shi)專門用(yong)(yong)于檢(jian)測(ce)固體制(zhi)劑(ji)(如(ru)片劑(ji)、膠囊等(deng))溶(rong)(rong)(rong)出(chu)(chu)度的(de)藥(yao)(yao)(yao)物(wu)(wu)試驗(yan)儀器(qi),它(ta)能模擬人體的(de)胃腸消化運動過程,配合紫外分(fen)光(guang)光(guang)度計(ji)可檢(jian)測(ce)藥(yao)(yao)(yao)物(wu)(wu)制(zhi)劑(ji)的(de)溶(rong)(rong)(rong)出(chu)(chu)度。是(shi)一種應用(yong)(yong)廣(guang)泛(fan)的(de)藥(yao)(yao)(yao)學(xue)儀器(qi),在固體藥(yao)(yao)(yao)物(wu)(wu)的(de)質量(liang)控制(zhi)、藥(yao)(yao)(yao)品研發與(yu)生產的(de)質量(liang)控制(zhi)以及實驗(yan)教學(xue)上都有很(hen)多應用(yong)(yong),主(zhu)要功能是(shi)測(ce)量(liang)藥(yao)(yao)(yao)物(wu)(wu)的(de)溶(rong)(rong)(rong)解速率和溶(rong)(rong)(rong)出(chu)(chu)濃度,進而繪制(zhi)出(chu)(chu)溶(rong)(rong)(rong)出(chu)(chu)度曲線。銳拓(tuo)在線紫外自(zi)動檢(jian)測(ce)溶(rong)(rong)(rong)出(chu)(chu)系(xi)統(RT600-UV)是(shi)銳拓(tuo)儀器(qi)在第(di)三代溶(rong)(rong)(rong)出(chu)(chu)操作系(xi)統基(ji)礎上推(tui)出(chu)(chu)的(de),RT600-UV系(xi)統包括溶(rong)(rong)(rong)出(chu)(chu)儀,自(zi)動取樣工作站和紫外-可見分(fen)光(guang)光(guang)度計(ji)。RT600-...

  • 2022-12-01

    前言:美國FDA于2022年10月(yue)發(fa)布了最(zui)新工業指(zhi)南(nan)《InVitroPermeationTestStudiesforTopicalDrugProductsSubmittedinANDAsGuidanceforIndustry》,指(zhi)南(nan)中469-475行(xing)提(ti)到:“Theequipment,methodologies,andstudyconditionsusedintheIVPTpilotstudy(andtheeventualIVPTpivotalstudy)shouldbeapp...

  • 2022-11-16

    流池法(fa)(fa)(fa)溶(rong)出(chu)(chu)度(du)(du)(du)方法(fa)(fa)(fa)(FlowThroughCellmethod)是一種新型的(de)溶(rong)出(chu)(chu)度(du)(du)(du)檢查方法(fa)(fa)(fa),已收錄于歐洲藥典(dian),美國藥典(dian),日本(ben)藥典(dian)中,它(ta)可克服日前槳(jiang)法(fa)(fa)(fa)、籃(lan)法(fa)(fa)(fa)無法(fa)(fa)(fa)解決的(de)困(kun)難,比槳(jiang)法(fa)(fa)(fa)的(de)感知度(du)(du)(du)更高(gao),可克服因藥片(pian)崩(beng)潰堆(dui)積所(suo)導致的(de)飽(bao)和(he)等(deng)問題。不(bu)僅(jin)適用(yong)于片(pian)劑(ji)(ji)、膠囊(nang)劑(ji)(ji)釋制劑(ji)(ji)的(de)溶(rong)出(chu)(chu)度(du)(du)(du)測(ce)定,更可對粉末、栓劑(ji)(ji)、顆粒劑(ji)(ji)和(he)植入劑(ji)(ji)等(deng)多種劑(ji)(ji)型直接測(ce)試(shi),在制藥公司(si)研究制劑(ji)(ji),或原研藥變(bian)更劑(ji)(ji)型等(deng)研究中得到(dao)大量應用(yong)。銳拓RT7流池法(fa)(fa)(fa)溶(rong)出(chu)(chu)系統包括(kuo):流通池溶(rong)出(chu)(chu)裝置、溶(rong)媒輸(shu)送(song)工作站和(he)自動取樣工作站。可升(sheng)級到(dao)UV或HPLC...

  • 2022-10-17

    溶(rong)(rong)出儀(yi)是(shi)測(ce)定(ding)(ding)藥(yao)(yao)物溶(rong)(rong)出度的(de)檢驗(yan)工(gong)具。溶(rong)(rong)出儀(yi)在(zai)使用(yong)(yong)前必須要進(jin)行校(xiao)正(zheng),目的(de)就是(shi)要將影響因素減少到最低。目前溶(rong)(rong)出儀(yi)校(xiao)正(zheng)主(zhu)要有(you)2種方式,機(ji)械校(xiao)正(zheng)和化學校(xiao)正(zheng)。機(ji)械校(xiao)正(zheng)就是(shi)按照儀(yi)器(qi)制造(zao)商提供的(de)質(zhi)量標準(zhun)和藥(yao)(yao)典附(fu)錄(lu)中(zhong)的(de)規(gui)定(ding)(ding),對溶(rong)(rong)出儀(yi)部件(jian)的(de)尺寸、位置、轉速(su)、搖擺度、中(zhong)心度等指標和參數進(jin)行檢測(ce)。化學校(xiao)正(zheng)和儀(yi)器(qi)合格評(ping)(ping)定(ding)(ding)中(zhong)的(de)性能(neng)評(ping)(ping)定(ding)(ding)(PQ)的(de)作(zuo)用(yong)(yong)相同,指在(zai)正(zheng)常的(de)操作(zuo)環境和規(gui)定(ding)(ding)的(de)溶(rong)(rong)出條件(jian)下,測(ce)定(ding)(ding)標準(zhun)片(pian)或顆(ke)粒的(de)溶(rong)(rong)出量,并與(yu)標準(zhun)片(pian)說明書中(zhong)規(gui)定(ding)(ding)的(de)溶(rong)(rong)出范圍進(jin)行比較,確定(ding)(ding)溶(rong)(rong)出儀(yi)的(de)性能(neng)指標是(shi)否(fou)符(fu)合藥(yao)(yao)典要求,也可稱(cheng)為...

  • 2022-09-23

    不(bu)(bu)(bu)了(le)(le)(le)解溶(rong)出儀(yi)一(yi)(yi)定不(bu)(bu)(bu)要(yao)(yao)(yao)隨意應(ying)用不(bu)(bu)(bu)論是(shi)(shi)生產還(huan)是(shi)(shi)生活之中,我們(men)會(hui)使(shi)用到很多種(zhong)類的(de)(de)設(she)(she)備(bei)(bei),各種(zhong)設(she)(she)備(bei)(bei)的(de)(de)應(ying)用實際上并不(bu)(bu)(bu)是(shi)(shi)困難的(de)(de)事情,有(you)(you)些設(she)(she)備(bei)(bei)只(zhi)要(yao)(yao)(yao)是(shi)(shi)大(da)家稍(shao)微用心一(yi)(yi)些,就(jiu)可以對其使(shi)用要(yao)(yao)(yao)求等有(you)(you)所了(le)(le)(le)解,并且正確的(de)(de)應(ying)用這(zhe)(zhe)(zhe)(zhe)種(zhong)設(she)(she)備(bei)(bei)。像溶(rong)出儀(yi)的(de)(de)應(ying)用,似乎也不(bu)(bu)(bu)是(shi)(shi)那么的(de)(de)困難,不(bu)(bu)(bu)過想(xiang)要(yao)(yao)(yao)有(you)(you)效的(de)(de)發揮這(zhe)(zhe)(zhe)(zhe)種(zhong)設(she)(she)備(bei)(bei)的(de)(de)作(zuo)用,就(jiu)需要(yao)(yao)(yao)對其有(you)(you)更(geng)多的(de)(de)了(le)(le)(le)解。對于有(you)(you)使(shi)用溶(rong)出儀(yi)需求的(de)(de)企業(ye),一(yi)(yi)定要(yao)(yao)(yao)讓有(you)(you)專業(ye)知識的(de)(de)人(ren)負(fu)責這(zhe)(zhe)(zhe)(zhe)種(zhong)設(she)(she)備(bei)(bei)的(de)(de)操作(zuo),而不(bu)(bu)(bu)是(shi)(shi)讓一(yi)(yi)些*都不(bu)(bu)(bu)了(le)(le)(le)解這(zhe)(zhe)(zhe)(zhe)種(zhong)設(she)(she)備(bei)(bei)的(de)(de)人(ren)隨意的(de)(de)操作(zuo)。如果隨意的(de)(de)應(ying)用這(zhe)(zhe)(zhe)(zhe)種(zhong)設(she)(she)備(bei)(bei),有(you)(you)時候不(bu)(bu)(bu)但不(bu)(bu)(bu)能發揮設(she)(she)備(bei)(bei)的(de)(de)作(zuo)用,還(huan)會(hui)給設(she)(she)備(bei)(bei)...

  • 2022-09-14

    崩(beng)解(jie)(jie)儀(yi)(yi)是使用(yong)你得(de)先了(le)解(jie)(jie)到這些基礎知識崩(beng)解(jie)(jie)儀(yi)(yi)是機電一體藥檢儀(yi)(yi)器,它(ta)是根據藥典有(you)關片劑、丸劑等崩(beng)解(jie)(jie)時(shi)限檢測的(de)(de)(de)規定研發生產的(de)(de)(de)。崩(beng)解(jie)(jie)儀(yi)(yi)的(de)(de)(de)使用(yong)注(zhu)意(yi)事項:1、要(yao)把智能崩(beng)解(jie)(jie)儀(yi)(yi)放在堅固的(de)(de)(de)無振動(dong)共鳴的(de)(de)(de)操作臺上,環(huan)境(jing)干燥通風,不(bu)要(yao)受潮。2、保(bao)證供電電源應有(you)地線(xian)而且(qie)接地良好。3、水槽中沒(mei)有(you)水時(shi),嚴格(ge)禁止啟動(dong)加(jia)熱,不(bu)然會造成加(jia)熱器的(de)(de)(de)損(sun)壞。4、為防止水槽中的(de)(de)(de)水虹吸倒流,主(zhu)機箱后面、水槽上方引出的(de)(de)(de)氣導管要(yao)通過尼龍(long)單向閥連接,不(bu)能接反(fan),接反(fan)會導致(zhi)沒(mei)有(you)氣泡(pao)產生。5、崩(beng)解(jie)(jie)試驗完畢,關掉(diao)電源開關。如果較長時(shi)間不(bu)...

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